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In the monoaminergic neurotransmitter deficiency hypothesis, it is posited that depressive symptoms arise from insufficient levels of monoamine neurotransmitters such as 5-HT, norepinephrine (NE), and/or dopamine (DA) (157)

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3-(1H-benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1, 2, 4-oxadiazole (DDO 7232), a novel potent Nrf 2/ARE inducer, ameliorates DSS-induced murine colitis and protects NCM460 cells against oxidative stress via ERK1/2 phosphorylation